![]() ![]() gondii than female Tepehuanos of the same age. Male Tepehuanos aged 31-50 years showed a significantly higher frequency of exposure to T. Also, 15 (9.6%) subjects had anti-Toxoplasma IgM antibodies. Of the 156 Tepehuanos (mean age 31.03Â☑6.71 years), 35 (22.4%) had anti-Toxoplasma IgG antibodies. We therefore investigated the presence of anti-Toxoplasma IgG and IgM antibodies in 156 Tepehuanos, an indigenous ethnic group in Durango State in northern Mexico, using ELISAs. The epidemiology in specific populations (i.e., in indigenous ethnic groups) is not well studied. The epidemiology of Toxoplasma gondii infection is known to depend on a number of behavioral factors, including contact with animals and eating habits. Seroepidemiology of Toxoplasma gondii infection in Tepehuanos in Durango, Mexico.Īlvarado-Esquivel, Cosme Estrada-MartÃnez, Sergio GarcÃa-López, Claudia Rosalba Rojas-Rivera, Amparo Sifuentes-Ãlvarez, Antonio Liesenfeld, Oliver Although these findings are disappointing for the use in diagnosis, the richer response in saliva might indicate local exposure to T. gondii antigens without systemic infection thus, saliva might be reflecting a local (protective?) response against this protozoan. We also observed that most samples of saliva that were positive for one IgG subclass were also positive for at least 2 of the other 3 this contrasted with findings in serum, wherein each person was positive almost exclusively for one subclass, as demonstrated before by us and other researchers. The levels of IgA, IgG2, IgG3 and IgG4 antibodies and, to a lesser extent, IgG1 did not correlate between saliva and serum, that is, most cases that were positive for one Ig class in a sample were negative or very low in the other, and vice versa. ![]() In this work, we determined the levels of IgG, IgA, IgG1, IgG2, IgG3 and IgG4 anti-Toxoplasma gondii antibodies in paired saliva and serum samples from 91 women by indirect ELISA using a crude extract of the RH strain. Some IgG subclasses are related to clinical outcome in the congenital form. What do anti-Toxoplasma gondii IgA and IgG subclasses in human saliva indicate?Ĭañedo-Solares, I Gómez-Chávez, F Luna-Pastén, H Ortiz-AlegrÃa, L B Flores-GarcÃa, Y Figueroa-Damián, R Macedo-Romero, C A Correa, Dĭiagnostic tests for toxoplasmosis are based on serological techniques due to their high sensitivity. ![]()
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